About Metabolomics

Shown here is a trace from a non-targeted metabolomics run, leading to typical coverage of 500 – 2,000 annotated metabolites.

Metabolomics is the simultaneous measurement of hundreds to thousands of small molecule metabolites in a cell, tissue or bio-fluid. Unlike other –omics techniques, metabolomics provides a direct measurement of real-time cellular physiology to reveal with unprecedented detail the markers of disease, treatment response, and biological mechanism.

While a limited number of academic and industrial researchers and clinicians have demonstrated the potential of metabolomics, significant time and cost constraints have limited the broader application of this technology.

 

For the first time, General Metabolics brings scale to metabolomics to allow these powerful studies to become a regular part of the R&D workflow to identify markers of disease, to assess target engagement, to mechanistically link targets to broader cellular physiology or to evaluate patient response to treatment.

Interested to read more about how GMet technology is being used to advance and scale metabolomics research and bring new insights to industry?

Following are selected peer-reviewed publications with General Metabolics founders and advisors.

Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in E. coli.

Nature Communications, 2019

Metabolomics Identifies a Biomarker Revealing in Vivo Loss of Functional ß-Cell Mass Before Diabetes Onset.

Diabetes, 2019

High-throughput dynamic metabolomics identifies mode of action for uncharacterized antimicrobial compounds.

Science Translational Medicine, 2018

Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response.

Immunity, 2018

Synthesis and degradation of FtsZ quantitatively predicts the first cell division in starved bacteria.

Molecular Systems Biology, 2018

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Cell, 2018

Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.

Nature Methods, 2017

Genomewide landscape of gene–metabolome associations in Escherichia coli.

Molecular Systems Biology, 2017

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Cell Metabolism, 2017

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.

Nature, 2017

GMet technology has been used in over 50 peer-reviewed publications.