Search Resources
Netherlands Metabolomics Centre
Through active community building and collaboration within the field, the NMC functions as a liaison between groups developing and applying metabolomics technology, actively promoting the transfer of knowledge and technology in the field of metabolomics through a network of committed partners.
Swiss Metabolomics Society
The Swiss Metabolomics Society was founded in 2014 to foster the interactions and collaborations among academic researchers and industrial partners, to promote education and outreach activities. (from the Swiss Metabolomics Society website)
MassBank of North America
MassBank of North America (MoNA) is a metadata-centric, auto-curating repository designed for efficient storage and querying of mass spectral records. It intends to serve as a the framework for a centralized, collaborative database of metabolite mass spectra, metadata and associated compounds.
Metabolomics Association of North America (MANA)
Established in 2018, the Metabolomics Association of North America (MANA) comprises of members from Canada, Mexico, and the USA who prioritize cooperation, coordination, and the advancement of the field. MANA’s goal is to foster the growth and development of metabolomics. (from MANA’s website)
Metabolomics Society
The Metabolomics Society is dedicated to promoting the growth, use and understanding of metabolomics in the life sciences. (from The Metabolomics Society website)
Lipid Maps
LIPID Metabolites And Pathways Strategy (LIPID MAPS®) is a multi-institutional supported website and database that provides access to a large number of globally used lipidomics resources. (from LipidMaps website)
GNPS
GNPS is a web-based mass spectrometry ecosystem that aims to be an open-access knowledge base for community-wide organization and sharing of raw, processed, or annotated fragmentation mass spectrometry data (MS/MS). (from the GNPS website)
BRENDA
BRENDA (The Comprehensive Enzyme Information System) is an information system representing one of the most comprehensive enzyme repositories. It is an electronic resource that comprises molecular and biochemical information on enzymes that have been classified by the IUBMB. (from the BRENDA Wikipedia page)
General Metabolics Opens New US-based Laboratory in Boston
General Metabolics (GMet) is excited to announce the opening of its new U.S.-based laboratory in Boston, Massachusetts. After previously operating out of the ETH in Zurich, Switzerland, metabolomics studies from our U.S. and international clients will now be handled exclusively by GMet’s Boston laboratory.
General Metabolics’ Boston Laboratory Contracts Over 10,000 Samples
General Metabolics (GMet) is excited to report that as of February 2020 it has contracted over 10,000 samples for non-targeted metabolomics analysis at its Boston laboratory.
METLIN
The METLIN Metabolite and Chemical Entity Database is the largest repository of experimental tandem mass spectrometry and neutral loss data acquired from standards. (from the METLIN Wikipedia page)
Reactome
Reactome is a free online database of biological pathways. There are several Reactomes that concentrate on specific organisms, the largest of which is focused on human biology.
ChEBI
Chemical Entities of Biological Interest, also known as ChEBI is a chemical database and ontology of molecular entities focused on ‘small’ chemical compounds, that is part of the Open Biomedical Ontologies (OBO) effort at the European Bioinformatics Institute (EBI). (from the ChEBI Wikipedia page)
MetaboLights
MetaboLights is a data repository founded in 2012 for cross-species and cross-platform metabolomic studies that provides primary research data and meta data for metabolomic studies as well as a knowledge base for properties of individual metabolites. (from the Metabolights Wikipedia page)
HMDB
The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body. (from HMDB’s website)
KEGG
Initiated in 1995, KEGG (Kyoto Encyclopedia of Genes and Genomes) is a collection of databases dealing with genomes, biological pathways, diseases, drugs, and chemical substances. (from the KEGG Wikipedia page)
Application Spotlight: ULLAND ET AL. 2017
Alzheimer’s Disease is a debilitating neurodegenerative illness for which there are currently no effective treatments. Mutations in the AD-associated gene TREM2 have been implicated in dysregulated microglial autophagy – the degradation of intracellular structures in immune cells that regulate homeostasis in the central nervous system.
Diether M, Nikolaev Y, Allain Fh, Sauer U. Systematic Mapping of Protein-metabolite Interactions in Central Metabolism of Escherichia Coli.
Mol Syst Biol. 2019 Aug;15(8):e9008. doi: 10.15252/msb.20199008. PMID: 31464375; PMCID: PMC6706640.
Zampieri, M., Hörl, M., Hotz, F. Et Al. Regulatory Mechanisms Underlying Coordination of Amino Acid and Glucose Catabolism in Escherichia Coli.
Nat Commun 10, 3354 (2019).
Blasche S, Kim Y, Mars Rat, Machado D, Maansson M, Kafkia E, Milanese a, Zeller G, Teusink B, Nielsen J, Benes V, Neves R, Sauer U, Patil Kr. Metabolic Cooperation and Spatiotemporal Niche Partitioning in a Kefir Microbial Community.
Nat Microbiol. 2021 Feb;6(2):196-208. doi: 10.1038/s41564-020-00816-5. Epub 2021 Jan 4. PMID: 33398099; PMCID: PMC7610452.
Sergushichev, a., Et Al. Gam: a Web-service for Integrated Transcriptional and Metabolic Network Analysis.
Nucleic Acids Research 2016, 44(W1): W194-200.
Holbrook-smith, D. Et Al. High-throughput Metabolomics Predicts Drug–target Relationships for Eukaryotic Proteins.
Mol Systems Biology 2022, 18(2): e10767.
Jha, a., Et Al. Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules That Regulate Macrophage Polarization.
Immunity 2015, 42(3): 419–430. doi: 10.1016/j.immuni.2015.02.005.
Williams EG, Pfister N, Roy S, Statzer C, Haverty J, Ingels J, Bohl C, Hasan M, Čuklina J, Bühlmann P, Zamboni N, Lu L, Ewald CY, Williams RW, Aebersold R. Multiomic profiling of the liver across diets and age in a diverse mouse population.
Cell Syst. 2022 Jan 19;13(1):43-57.e6.
Mitroulis, I. et al. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.
Cell 2018, 172(1-2):147-161.
Presented Abstract, Rheos Medicines: Camacho D., et al. Transcriptional Subsetting of SLE Patient Cohorts Based on Metabolic Pathway Activity [abstract].
Arthritis Rheumatol. 2021, 73 (suppl 9).
Fuhrer, T., et al. High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection time-of-Flight Mass Spectrometry.
Analytical Chemistry 2011, 83(18):7074-80.
Kazak, L., et al. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Cell Metabolism 2017, 26(4):660-671.
Cherkaoui S, Durot S, Bradley J, Et Al. A Functional Analysis of 180 Cancer Cell Lines Reveals Conserved Intrinsic Metabolic Programs.
Mol Syst Biol. 2022;18(11):e11033.
Lingzi, L., et al. Metabolomics Identifies a Biomarker Revealing in Vivo Loss of Functional ß-Cell Mass Before Diabetes Onset.
Diabetes 2019, 68(12):2272-2286. doi: 10.2337/db19-0131.
Xao, T., et al. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
Nature 2017, 548(7666):228-233.
Geiger, R. et al. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.
Cell 2016, 167: 829–842.
Temba, G.S., Et Al. Urban Living in Healthy Tanzanians is Associated With an Inflammatory Status Driven by Dietary and Metabolic Changes.
Nature Immunology 2021, 22:287–300.
The Long-term Genetic Stability and Individual Specificity of the Human Gut Microbiome
Cell. 2021;184(9):2302-2315.e12.
Influence of the Microbiome, Diet and Genetics on Inter-individual Variation in the Human Plasma Metabolome
Nature Medicine 2022, 28: 2333–2343
Application Spotlight: FU ET AL. 2020
Dana Farber Researchers use Untargeted Metabolomics to Identify New Metabolic Mechanisms in Pancreatic Cells Diabetes is an incurable metabolic disease that affects over 500 million people.
General Metabolics is Partnering with Dana Farber Cancer Institute
GMet is incredibly pleased to share the initial announcement of our partnership with Dana Farber Cancer Institute to create a state-of-the-art metabolomics facility at their Longwood site, providing on-campus access to GMet technologies for DFCI and Harvard researchers, and remote access to academic researchers world-wide.
