News & Publications
Following are selected peer-reviewed publications with General Metabolics founders and advisors.
Metabolomics Identifies a Biomarker Revealing in Vivo Loss of Functional ß-Cell Mass Before Diabetes Onset.
Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in E. coli.
Nature Communications, 2019
Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response.
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.
Synthesis and degradation of FtsZ quantitatively predicts the first cell division in starved bacteria.
Molecular Systems Biology, 2018
High-throughput dynamic metabolomics identifies mode of action for uncharacterized antimicrobial compounds.
Science Translational Medicine, 2018
Genomewide landscape of gene–metabolome associations in Escherichia coli.
Molecular Systems Biology, 2017
Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.
Nature Methods, 2017
Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Cell Metabolism, 2017
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.
GAM: a web-service for integrated transcriptional and metabolic network analysis.
Nucleic Acids Research, 2016
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection time-of-Flight Mass Spectrometry.
Analytical Chemistry, 2011