Uwe SauerFounder

Uwe Sauer received a Ph.D. in Microbiology from the University of Göttingen in 1992. He is currently Professor of Systems Biology at the Institute of Molecular Systems Biology of the ETH Zurich (Switzerland) with a research focus on complex regulation processes that control cellular metabolism. His lab has pioneered the development of quantitative mass spectrometry-based methods for metabolomics and flux analysis with a particular focus on high-throughput methods. Combining the skills of physicists, biologists, engineers and computer scientists, his interdisciplinary lab specializes in developing original computational and modeling approaches to generate testable hypotheses from large-scale metabolomics data. Prof. Sauer has about 70 publications in peer-reviewed journals over the last 5 years, and is a member of various editorial boards, scientific steering and advisory committees of international organizations and companies in systems biology and biotechnology.

Select Publications:

Oliveira AP, Dimopoulos S, Busetto AG, Christen S, Dechant R, Falter L, Chreghani MH, Jozefczuk S, Ludwig, Rudroff F, Schulz JC, Soulard A, Stracka D, Aebersold R, Buhmann JM, Hall MN, Peter M, Sauer U & J Stelling (2015). Inferring causal metabolic signals that regulate the dynamic TORC1-dependent transcriptome. Molecular Systems Biology 11: 802.

Sevin DC & Sauer U (2014). Ubiquinone accumulation improves osmotic stress tolerance in E. coli. Nature Chem Biol. 10: 266-272.

Chubukov V, Gerosa L, Kochanowski K & Sauer U (2014). Coordination of microbial metabolism. Nature Rev Microbiol. 12:327-40

Link H, Kochanowski K & Sauer U (2013). Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo. Nature Biotechnol. 31: 357-61.

Büscher JM, Liebermeister W, Jules M, Uhr M, Muntel J – 31 others – Bessieres P, Devine K, Harwood CR, Hecker M. Jarmer H, Klipp E, Lewis P, Molina F, Noirot P, Schwikowski B, van Dijl JM, Wilkinson AJ, Stelling J, Aymerich S & Sauer U (2012). Global network reorganization during dynamic adaptations of B. subtilis metabolism. Science 335: 1099-1103.