Nicola Zamboni obtained a Ph.D. in Biotechnology at the ETH Zurich in 2003. After a post-doctorate at the Stanford Genome Technology Center, he moved to the Institute of Molecular Systems Biology of ETH Zurich as in independent investigator. His research focuses on the development of experimental and computational methods purposed to study metabolism in cells and animals. His lab builds on own large scale, deep phenotyping of metabolism by mass spectrometry-based metabolomics, tracer-based flux analysis, and fluorescent biosensors to investigate in vivo metabolic networks and the molecular basis of their regulation. In the last 5 years, he co-authored > 30 papers including multiple articles in top life science journals.
Oliveira AP, Dimopoulos S, Busetto AG, Christen S, Dechant R, Falter L, Chreghani MH, Jozefczuk S, Ludwig, Rudroff F, Schulz JC, Soulard A, Stracka D, Aebersold R, Buhmann JM, Hall MN, Peter M, Sauer U & J Stelling (2015). Inferring causal metabolic signals that regulate the dynamic TORC1-dependent transcriptome. Molecular Systems Biology 11: 802.
Sevin DC & Sauer U (2014). Ubiquinone accumulation improves osmotic stress tolerance in E. coli. Nature Chem Biol. 10: 266-272.
Chubukov V, Gerosa L, Kochanowski K & Sauer U (2014). Coordination of microbial metabolism. Nature Rev Microbiol. 12:327-40
Link H, Kochanowski K & Sauer U (2013). Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo. Nature Biotechnol. 31: 357-61.
Büscher JM, Liebermeister W, Jules M, Uhr M, Muntel J – 31 others – Bessieres P, Devine K, Harwood CR, Hecker M. Jarmer H, Klipp E, Lewis P, Molina F, Noirot P, Schwikowski B, van Dijl JM, Wilkinson AJ, Stelling J, Aymerich S & Sauer U (2012). Global network reorganization during dynamic adaptations of B. subtilis metabolism. Science 335: 1099-1103.